Meditations on the bringing of a drug to market

In the marvellous Dorothy Dunnett novel King Hereafter there are a number of set pieces during which our heroine, the radiant, ravishing, self-willed Groa (Ingebjorg) is given an opportunity to participate in the councils of the great.  The men will sit around after supper talking, and drinking, but in moderation and in consideration of their dignity, and will say unbelievably cryptic things and then pause and look at each other like something out of a fricking Ingmar Berman movie.  Our heroine will learn that it behooves one to only have the best information to share with the menfolks or stay silent.

At one point, one of the menfolks says something, and there’s a pause, and somebody else says, “Is that a good thing?” and the response of the king is to say “It’s an interesting thing,” and then there’s another one of these massive, borborygmic pauses.

Such is my emotion on learning that there’s this thing on the internet (from University of Arkansas for Medical Sciences (2008, January 9)). Reversal Of Alzheimer’s Symptoms Within Minutes In Human Study. about immediate amelioration of Alzheimer symptoms – on one person!  One person?  Is it a good thing?  Possibly.  It’s an interesting thing, and that’s because we all imagine our deaths, and spending 10 or 15 years cuckoo and non-participatory and wacky-tacka aforehand is not how most of us want to go, however often and with however much fear we may foresee it.  Supposing this stuff works?  They jam some stuff in your cerebrospinal fluid, and it either hoovers up the bad crap that is preventing your brain from working properly and actually spits it out in a format that your body’s clean up crew can deal with, or it kicks it out of where it’s binding to, or does something else I can’t imagine or describe.  Further suppose they figure out a way of getting it into you that doesn’t involve making holes in your spine, always a task fraught with hazard.  Interestingly enough it’s an offlabel use of an existing drug, etanercept.  Man, there are so many offlabel uses for so many drugs.  Some of them are downright criminal and ought to be dealt with summarily, but others should receive placid encouragement.  Is this application of etanercept such a case, or is it just another bunch of goddamned carnies with a stake in the outcome beating on the side of a barrel?  Time will tell.
Oh, and I watched the first 2/3rds of Hot Fuzz tonight.  I couldn’t stand to watch all of it, as the first part of the movie was delightful, and the last third of carnage was not…. at least to my view.  I’m dreffle tired of 25 minute shootouts, although I really liked the shootout in 3:10 to Yuma.

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Born when atmospheric carbon was 316 PPM. Settled on MST country since 1997. Parent, grandparent.

2 thoughts on “Meditations on the bringing of a drug to market”

  1. Borborygmic indeed. A delightful word, with few opportunities in ordinary discourse to be found for its us. Onomatopoeic, too, which adds to its charm.

    The N of 1 problem with that drug study – it is a real problem, and the results must be weighed accordingly. I think the findings must have been remarkable for the researchers to go public so early.

    Off-label is how Viagra got its start. Go figure.

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